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1Research and Innovation Unit, RHU BioArt Lung 2020,Marie Lannelongue Hospital, 2Phenotypic and Biomarker Core Laboratory, Cardiovascular Institute,Stanford University, 3Department of pathology,Marie Lannelongue Hospital, 4Department of pathology,UCSF School of Medicine, 5Department of thoracic surgery, Hopital Nord, APHM,Aix-Marseille University
Capítulos
- 00:04Introduction
- 00:39Catheter Placement
- 01:44Echocardiography
- 02:19Right Heart Catheterization and Pressure Volume Loop Acquisition
- 03:20Acute Right Heart Failure Induction
- 03:58Pressure Overload with Iterative Pulmonary Embolism Induction
- 04:40Systemic Hemodynamic Restoration
- 05:30Results: Representative Acute Right Heart Failure Phenotype Analyses
- 07:07Conclusion
Presentiamo un protocollo per indurre e fenotipizzare un'insufficienza cardiaca destra acuta in un modello animale di grandi dimensioni con ipertensione polmonare cronica. Questo modello può essere utilizzato per testare interventi terapeutici, per sviluppare metriche cardiache giuste o per migliorare la comprensione della fisiopatologia acuta dell'insufficienza cardiaca destra.
Tags
Keywords: Acute Right Heart FailureChronic Thromboembolic Pulmonary HypertensionLarge Animal ModelInductionPhenotypingVolume OverloadPressure OverloadSeldinger MethodJugular VeinFemoral ArteryFemoral VeinBalloon Dilation CatheterEchocardiographyRight Heart CatheterizationSwan-Ganz CatheterThermodilutionPressure-volume Loop
