Waiting
Processando Login

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Chemistry / Efficient Construction of Drug-like Bispirocyclic …
JoVE Journal
Chemistry

É necessário ter uma assinatura JoVE para assistir este Faça login ou comece sua avaliação gratuita.

JoVE Journal Chemistry
Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
 

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Article DOI: 10.3791/59155-v • 10:17 min • February 7th, 2019
February 7th, 2019 •
1, 2, 2, 2
1School of Basic Medical Sciences, Lanzhou University, 2School of Pharmaceutical Sciences, Sun Yat-sen University

Capítulos

Resumo
Automatic Translation

Enantiomerically enriched bispiro[γ-butyrolactone-pyrrolidin-4,4'-pyrazolone] skeletons are asymmetrically synthesized through a simple organocatalytic 1,3-dipolar cycloaddition reaction.

Tags

Keyword Extraction: Drug-like Bispirocyclic Scaffolds Organocatalytic Cycloadditions α-imino γ-lactones Alkylidene Pyrazolones Bipolar Cycloaddition Bispirocyclic Compounds Natural Products Biological Activities Chiral Spiral Centers High Yields Stereoselectivity Pyrazolone Hydrazine Ethyl Acetoacetate α-arylidiene Pyrazolinone Benzaldehyde Magnesium Oxide Acetonitrile
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter