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植入异丙酮醇微型泵，以诱导小鼠心力衰竭
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JoVE Journal Medicina
Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
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植入异丙酮醇微型泵，以诱导小鼠心力衰竭

DOI:
10.3791/59646-v

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05:08 min

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October 03, 2019

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, , , , ,
1Department of Anesthesiology,University of California, 2Department of Medicine,University of California, 3Department of Microbiology, Immunology & Molecular Genetics,University of California, 4Department of Molecular, Cell, and Developmental Biology,University of California

Capítulos

  • 00:04Título
  • 00:40Isoproterenol (ISO) Osmotic Pump Preparation
  • 02:00ISO Osmotic Pump Surgical Implantation
  • 03:17Results: Representative Changes in Echocardiographic Measures in Different Mouse Strains and After Isoproterenol
  • 04:06Conclusion

Summary

Tadução automática

Tadução automática

通过植入的渗透泵长期给用异丙酮醇，已被广泛用于模拟小鼠的晚期心力衰竭。在这里，我们描述了手术微型泵植入在持续异丙酮醇给3周内的详细方法，以及成功创建模型的超声心动图评估。

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