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Implantation af en Isoproterenol-mini pumpe for at inducere hjertesvigt i mus
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JoVE Journal Medicina
Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

Implantation af en Isoproterenol-mini pumpe for at inducere hjertesvigt i mus

DOI:
10.3791/59646-v

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05:08 min

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October 03, 2019

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, , , , ,
1Department of Anesthesiology,University of California, 2Department of Medicine,University of California, 3Department of Microbiology, Immunology & Molecular Genetics,University of California, 4Department of Molecular, Cell, and Developmental Biology,University of California

Capítulos

  • 00:04Título
  • 00:40Isoproterenol (ISO) Osmotic Pump Preparation
  • 02:00ISO Osmotic Pump Surgical Implantation
  • 03:17Results: Representative Changes in Echocardiographic Measures in Different Mouse Strains and After Isoproterenol
  • 04:06Conclusion

Summary

Tadução automática

Tadução automática

Den kroniske administration af izoproterenol via en implanteret osmotisk pumpe er blevet brugt bredt til at efterligne fremskreden hjerteinsufficiens i mus. Her beskriver vi detaljerede metoder i kirurgisk mini-pumpe implantation til kontinuerlig izoproterenol administration over 3 uger, samt ekkokardiografisk vurdering for den vellykkede model skabelse.

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