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Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment
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JoVE Journal Medicina
Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment

Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment

DOI:
10.3791/60392-v

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08:24 min

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May 25, 2020

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, , , , ,
1Cardiology Division, Department of Medicine, Queen Mary Hospital,University of Hong Kong, 2Shenzhen Institutes of Research and Innovation,University of Hong Kong

Capítulos

  • 00:04Introduction
  • 00:46Pacemaker Implantation
  • 01:39Invasive Pressure Volume Loop Analysis
  • 02:55Myocardial Infarction (MI) Induction
  • 04:03Stem Cell Injection
  • 05:02Intracardiac Programmed Electrical Stimulation
  • 06:01Results: Representative Cardiac Function, Morphology, Cell Survival, and Inducible Ventricular Arrhythmia
  • 07:41Conclusion

Summary

Tadução automática

Tadução automática

We sought to establish a swine model of heart failure induced by left circumflex artery blockage and rapid pacing to test the effect and safety of intramyocardial administration of stem cells for cell-based therapies.

Tags

Swine ModelPost-myocardial InfarctionHeart FailureStem Cell TreatmentLeft Circumflex Artery BlockageRapid PacingInfarct SizeLeft Ventricle InjectionRight Carotid ArteryJugular VeinPacemakerRight Femoral ArteryFemoral VeinPressure Volume CatheterMyocardial InfarctionVentricular ArrhythmiasAmiodaroneLidocaineCoronary Angiography

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