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大鼠关节内注射单碘乙酸酯诱导的骨关节炎疼痛模型
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JoVE Journal Medicina
Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats
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大鼠关节内注射单碘乙酸酯诱导的骨关节炎疼痛模型

DOI:
10.3791/60649-v

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08:09 min

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May 20, 2020

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, , , , ,
1The First Affiliated Hospital,Zhejiang Chinese Medical University, 2College of Pharmaceutical Science,Zhejiang Chinese Medical University

Capítulos

  • 00:04Introduction
  • 00:47Intra‐Articular Mono‐Iodoacetate (MIA) Injection
  • 01:48Mechanical Withdrawal Threshold (MWT)
  • 03:00Thermal Withdrawal Latency (TWL)
  • 04:17Gait Pattern Analyses
  • 05:39Results: Representative MIA Development and Characterization
  • 07:16Conclusion

Summary

Tadução automática

Tadução automática

本研究描述了大鼠关节内注射单碘乙酸酯的方法，并讨论了由此产生的疼痛相关行为和组织病理学变化，为今后的应用提供参考。

Tags

OsteoarthritisPain ModelMono-iodoacetateIntra-articular InjectionRatsPaw Withdrawal ThresholdThermal Withdrawal LatencyBehavioral Testing

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