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A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
 

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Article DOI: 10.3791/61531-v • 06:23 min • September 22nd, 2020
September 22nd, 2020 •
1, 1, 1, 1, 1, 1, 1, 1,2, 1,3
1Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China, 2Key Laboratory of Neurological Diseases of Chinese Ministry of Education, The School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000,China, 3Department of Pharmacology, School of Basic Medical Science; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China

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Presented here is a protocol for chronic sleep fragmentation (CSF) model achieved by an electrically controlled orbital rotor, which could induce confirmed cognitive deficit and anxiety-like behavior in young wild-type mice. This model can be applied to explore the pathogenesis of chronic sleep disturbance and related disorders.

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Chronic Sleep Fragmentation Vibrating Orbital Rotor Cognitive Deficit Anxiety-like Behavior Neurodegenerative Disease Protocol Interruptions During Sleep Standardized Interventions Repeatable Behavioral Outcomes Pathological Outcomes Depression Alzheimer's Disease Chronic Sleep Disturbance Underlying Disease Wild-type Male Mice CSF Modeling Control Cages Social Isolation Stress Surrounding Environment Water Bottles With Ball Valve Tips Water Leakage Prevention
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