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一种新生儿啮齿动物气管内滴注药物治疗肺部疾病的微创方法

JoVE Journal
Medicina

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JoVE Journal Medicina

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease

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一种新生儿啮齿动物气管内滴注药物治疗肺部疾病的微创方法

DOI:

10.3791/61729-v

•

04:21 min

•

August 04, 2021

•

Tara Sudhadevi, Alison W Ha, Anantha Harijith

¹Department of Pediatrics,Case Western Reserve University

Capítulos

00:04Introduction
01:08Intratracheal Instillation (ITI) and Characterization Post Administration
03:07Results: Validation of Intratracheal Instillation Technique
03:50Conclusion

Summary

Tadução automática

这种将药物直接滴入新生儿啮齿动物气管的技术对于研究局部施用的药物或生物制剂对新生儿肺部疾病的影响非常重要。此外，该方法还可用于在动物模型中诱导肺损伤。

Tags

Keywords: Minimally Invasive Intratracheal Instillation Neonatal Rodents Lung Disease Anesthesia Trachea Vocal Cords Syringe Pipette Visual Assessment

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