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Zebrafish Model of Neuroblastoma Metastasis
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Zebrafish Model of Neuroblastoma Metastasis

Zebrafish Model of Neuroblastoma Metastasis

DOI:
10.3791/62416-v

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05:20 min

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March 14, 2021

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, , , ,
1Department of Biochemistry and Molecular Biology,Mayo Clinic College of Medicine, Mayo Clinic Cancer Center

Capítulos

  • 00:04Introduction
  • 00:57Outcross of LMO1 and MYCN Transgenic Lines to Create Metastatic Model
  • 02:11Visualizing Tumor Burden in Transgenic Zebrafish Lines
  • 03:17Results: Transgenic Zebrafish Model Overexpressing MYCN and LMO1 for Neuroblastoma Metastasis
  • 04:50Conclusion

Summary

Tadução automática

Tadução automática

This paper introduces the method of developing, characterizing, and tracking in real-time the tumor metastasis in zebrafish model of neuroblastoma, specifically in the transgenic zebrafish line with overexpression of MYCN and LMO1, which develops metastasis spontaneously.

Tags

ZebrafishNeuroblastomaMetastasisIn Vivo ImagingTumor DisseminationMYCNLMO1TransgenicEGFPFluorescence MicroscopeTumor ScreeningTumor-bearing FishTumor Cell Migration

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