Journal

Neurociência

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

JoVE Journal
Neurociência

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JoVE Journal Neurociência

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

DOI:

10.3791/62699-v

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08:27 min

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September 02, 2021

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Heather N. Currey, Nicole F. Liachko²

¹Geriatrics Research Education and Clinical Center,Veterans Affairs Puget Sound Health Care System, ²Division of Gerontology and Geriatric Medicine, Department of Medicine,University of Washington

Capítulos

00:04Introduction
00:45Radial Locomotion Assay
02:10Computer-Analyzed Swimming Assay
05:51Data Analysis
06:19Results: Analysis of the Crawling Speeds in Radial Locomotion and Thrashing in the Swimming Assay
07:48Conclusion

Summary

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This protocol describes two sensitive assays for discriminating among mild, moderate, and severe motor impairment in C. elegans models of amyotrophic lateral sclerosis, with general utility for C. elegans strains, with altered motility.

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

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Capítulos

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