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Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
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JoVE Journal Medicina
Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

DOI:
10.3791/62982-v

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09:31 min

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February 14, 2022

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, , , , , , , , , ,
1Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine,University of Alberta, 2Mazankowski Alberta Heart Institute, 3Faculty of Medicine and Dentistry,University of Alberta, 4Department of Surgery, Faculty of Medicine,University of Alberta, 5Ray Rajotte Surgical-Medical Research Institute (SMRI),University of Alberta, 6Alberta Transplant Institute, 7Canadian Donation and Transplantation Research Program

Capítulos

  • 00:05Introduction
  • 00:57Pneumonectomy
  • 02:58Placement of the Lungs onto the Ex‐Situ Lung Perfusion (ESLP) Apparatus
  • 04:35Initiation of Perfusion and Ventilation
  • 07:44Results: Analysis of Blood Gas and Functional Parameters During Evaluation Modes Over 12 Hours of ESLP and NPV‐ESLP
  • 08:57Conclusion

Summary

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This paper describes a porcine model of negative pressure ventilation ex situ lung perfusion, including procurement, attachment, and management on the custom-made platform. Focus is made on anesthetic and surgical techniques, as well as troubleshooting.

Tags

Normothermic Negative Pressure VentilationEx Situ Lung PerfusionLung FunctionLung MetabolismESLP DeviceNegative Pressure VentilationDonor LungsMarginal LungsJuvenile Pig LungsSternotomyCardiectomyMediastinal PleuraPulmonary LigamentTracheaEsophagusAorta

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