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JoVE Journal Cancer Research
Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
 

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Article DOI: 10.3791/63620-v • 09:17 min • September 13th, 2022
September 13th, 2022 •
1, 2, 2, 3, 2, 2,4
1Department of Neurology, Dartmouth-Hitchcock Medical Center, 2Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, 3Department of Neurosurgery, Dartmouth-Hitchcock Medical Center, 4Dartmouth Cancer Center, Dartmouth-Hitchcock Medical Center

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Proteomic dysregulation plays an important role in the spread of diffusely infiltrating gliomas, but several relevant proteins remain unidentified. Digital spatial processing (DSP) offers an efficient, high-throughput approach for characterizing the differential expression of candidate proteins that may contribute to the invasion and migration of infiltrative gliomas.

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Keywords: Digital Spatial Profiling DSP Protein Quantification Microenvironment Adult-type Diffusely Infiltrating Glioma Multiplexing Regions Of Interest Oncology Target Variability Malignant Growth Invasion Immunohistochemistry Tissue Microarray Blocking Solution Scanning Hydrophobic Barrier
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