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JoVE Journal Bioengineering
Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus (AAV) Capsid Variants
 

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus (AAV) Capsid Variants

Article DOI: 10.3791/64389-v • 09:20 min • October 18th, 2022
October 18th, 2022 •
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1Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, University of Heidelberg, 2BioQuant Center, BQ0030, University of Heidelberg, 3Cluster of Excellence CellNetworks, 4German Center for Infection Research (DZIF), 5German Center for Cardiovascular Research (DZHK)

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AAV peptide display library generation and subsequent validation through the barcoding of candidates with novel properties for the creation of next-generation AAVs.

Tags

Gene Therapy Vectors Engineering Barcoding Screening Adeno-associated Virus (AAV) Capsid Variants Recombinant Vectors Human Gene Therapy High-throughput Parallel Screening Therapeutic Transgenes Viral Dose Safety Applicability Promoter Engineering Gene Delivery Vehicles NGS Sequencing Data Python 3 Biopython
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