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In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus
JoVE Journal
Biologia do Desenvolvimento
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JoVE Journal Biologia do Desenvolvimento
In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus
DOI:

11:59 min

April 28, 2023

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Capítulos

  • 00:00Introduction
  • 00:48Surgical Procedure
  • 06:58Placing the Fetus Back and Closing the Wound
  • 08:21Post-Operative In Vivo Experiments
  • 09:28Results: Localized Effects of Blood Flow Manipulation in Near-Term and Preterm Fetus and Sheep
  • 11:06Conclusion

Summary

Tadução automática

The present protocol describes a method to deliver drugs and gene expression-modifying agents perivascularly in an in utero developing fetus. Importantly, the effect of drugs/agents on blood flow can be measured with the progression of pregnancy.

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