Chapter 11
Additional Roles of RNA
![Transcription Attenuation in Prokaryotes](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11620.jpg)
Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin…
![Riboswitches](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11621.jpg)
Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins.…
![Regulated mRNA Transport](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11624.jpg)
In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to…
![Leaky Scanning](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11625.jpg)
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start…
![RNA Interference](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/10804.jpg)
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its…
![MicroRNAs](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/10801.jpg)
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of…
![piRNA - Piwi-interacting RNAs](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11630.jpg)
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs…
![CRISPR and crRNAs](https://cloudfront.jove.com/files/media/science-education/science-education-thumbs/11631.jpg)
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to…
![Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts](https://cloudfront.jove.com/files/thumbs/54473_t.png)
Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts
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Human signal transducer and activator of transcription 3 (STAT3) is one of many genes containing a tandem splicing site. Alternative donor splice…
![Efficient Transcriptionally Controlled Plasmid Expression System for Investigation of the Stability of mRNA Transcripts in Primary Alveolar Epithelial Cells](https://cloudfront.jove.com/files/thumbs/60654_t.png)
Studying posttranscriptional regulation is fundamental to understanding the modulation of a given messenger RNA (mRNA) and its impact on cell…
![RNA Interference in Aquatic Beetles as a Powerful Tool for Manipulating Gene Expression at Specific Developmental Time Points](https://cloudfront.jove.com/files/thumbs/61477_t.png)
RNA Interference in Aquatic Beetles as a Powerful Tool for Manipulating Gene Expression at Specific Developmental Time Points
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RNA interference (RNAi) remains a powerful technique that allows for the targeted reduction of gene expression through mRNA degradation. This…