脑成像的情感对认知损害的影响调查
1Department of Psychiatry,University of Alberta, 2Centre for Neuroscience,University of Alberta, 3Department of Psychology,University of Illinois, 4Brain Imaging and Analysis Center,Duke University , 5Department of Psychiatry and Behavioral Sciences,Duke University , 6Mid-Atlantic Mental Illness Research Education and Clinical Center,VA Medical Center, 7Department of Psychology,Yale University, 8Neuroscience Program,University of Illinois, 9Beckman Institute for Advanced Science & Technology,University of Illinois
Summary
我们提出了一个协议，允许调解的情感对认知的不利影响，使用功能磁共振成像的神经机制的调查。该协议可用于健康和临床的参与者。
Abstract
情绪可以影响施加既提高 （例如，更好地为情绪事件的记忆 ），损害（例如，增加情感分心） 的影响（1审查）的认知。补充我们最近的协议 2描述的方法，让情感的记忆增强作用（ 见1，3-5）的神经关联的调查，在这里我们提出了一个协议，允许调查的不利影响神经关联情感对认知。这种方法的主要特点是，它允许之间的互惠调制腹侧神经系统活动的参与，参与更高层次的“冷”“热”情绪加工 （HotEmo系统），和背侧系统的鉴定认知/行政处理（ColdEx系统），这是与认知表现和个人行为的变化（1审查） 。由于其初始introduction 6已经证明，这种设计在澄清关于对认知的情感分心造成的不利影响神经关联的各方面，特别是通用和有影响力的的，与工作记忆（WM）为重点， 并由此应对7,11 ，既健康8-11和临床参与者12-14。
Protocol
一，任务设计，刺激，实验协议此协议的基本任务是一个延迟响应WM的任务，新任务无关的情绪和中性分心之间的备忘录和探头（见图1图说明原来的任务）的延迟间隔期间。事件相关的fMRI数据记录，而参与者执行此任务。作为感性的控制，具有相同的基本属性（例如，空间频率和亮度），也可以用来炒的实际分心版本。 <img src="/files/ftp_upload/2434/2434fig1.jpg" alt="图1"…
Discussion
这个实验设计提供了最初的脑成像的证据表明，对正在进行的认知过程，情感分心的不利影响带来HotEmo腹侧神经系统和ColdEx背系统之间的相互调制。这种背腹的分解与西医受损表现在情感分心 6的存在，一直在正常8-11，12-14临床系统复制，并改变其他条件，如睡眠剥夺10和18压力。更重要的是，它也证明是特定的情绪，正面和负面的 17?…
Disclosures
The authors have nothing to disclose.
Acknowledgements
金融衍生工具是支持由美国国家精神分裂症和抑郁症研究联盟和俄共从加拿大精神病学研究基金会奖的青年研究者奖。
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Tags
Brain ImagingEmotionCognitionEnhancing EffectImpairing EffectMemoryEmotional DistractibilityNeural CorrelatesProtocolVentral Neural SystemHot Emotion ProcessingDorsal SystemCold Cognitive ProcessingCognitive PerformanceIndividual Variations In BehaviorEmotional DistractionWorking MemoryCoping With DistractionHealthy ParticipantsClinical Participants
Cite This Article
Wong, G., Dolcos, S., Denkova, E., Morey, R., Wang, L., McCarthy, G., Dolcos, F. Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition. J. Vis. Exp. (60), e2434, doi:10.3791/2434 (2012).