Correlating के मानव prefrontal प्रांतस्था से fMRI सिग्नल व्यवहार प्रतिक्रियाएँ: संज्ञानात्मक प्रक्रियाओं की जांच कार्य विश्लेषण का उपयोग
Summary
हमारे शोध के लक्ष्य के व्यवहार के लिए मस्तिष्क गतिविधि के लिए सहसंबंधी है. सही व्यवहार उपायों और इमेजिंग तकनीक हमें मस्तिष्क व्यवहार रिश्तों को स्पष्ट करने के लिए अनुमति देते हैं.
Abstract
The aim of this methods paper is to describe how to implement a neuroimaging technique to examine complementary brain processes engaged by two similar tasks. Participants’ behavior during task performance in an fMRI scanner can then be correlated to the brain activity using the blood-oxygen-level-dependent signal. We measure behavior to be able to sort correct trials, where the subject performed the task correctly and then be able to examine the brain signals related to correct performance. Conversely, if subjects do not perform the task correctly, and these trials are included in the same analysis with the correct trials we would introduce trials that were not only for correct performance. Thus, in many cases these errors can be used themselves to then correlate brain activity to them. We describe two complementary tasks that are used in our lab to examine the brain during suppression of an automatic responses: the stroop1 and anti-saccade tasks. The emotional stroop paradigm instructs participants to either report the superimposed emotional ‘word’ across the affective faces or the facial ‘expressions’ of the face stimuli1,2. When the word and the facial expression refer to different emotions, a conflict between what must be said and what is automatically read occurs. The participant has to resolve the conflict between two simultaneously competing processes of word reading and facial expression. Our urge to read out a word leads to strong ‘stimulus-response (SR)’ associations; hence inhibiting these strong SR’s is difficult and participants are prone to making errors. Overcoming this conflict and directing attention away from the face or the word requires the subject to inhibit bottom up processes which typically directs attention to the more salient stimulus. Similarly, in the anti-saccade task3,4,5,6, where an instruction cue is used to direct only attention to a peripheral stimulus location but then the eye movement is made to the mirror opposite position. Yet again we measure behavior by recording the eye movements of participants which allows for the sorting of the behavioral responses into correct and error trials7 which then can be correlated to brain activity. Neuroimaging now allows researchers to measure different behaviors of correct and error trials that are indicative of different cognitive processes and pinpoint the different neural networks involved.
Protocol
Discussion
आदेश में काम करने के लिए संबंधित सक्रियण के एक नक्शे उत्पादन, मस्तिष्क क्षेत्रों की पहचान (या विरोधी saccade बनाम समर्थक saccade या तो Stroop में यानी, incongruent बनाम अनुकूल भावना और चेहरे की अभिव्यक्ति) स्कैन कार्यों के ?…
Disclosures
The authors have nothing to disclose.
Acknowledgements
राष्ट्रीय विज्ञान एवं इंजीनियरिंग अनुसंधान परिषद (NSERC) JFXD, स्वास्थ्य, न्यूयॉर्क विश्वविद्यालय और लेखक के संकाय द्वारा वित्त पोषित अतः ओंटारियो समस्या जुआ रिसर्च सेंटर (OPGRC) द्वारा पीएचडी धन है.
Materials
| Name of Equipment | Company |
| 3-Tesla MRI machine | Siemens Magnetom Trio (Erlangen, Germany) |
| iViewX Eye Tracking | SensoMotoric Instruments, Inc. |
| BrainVoyager QX software | Brain Innovation, Maastricht, The Netherlands |
| Four-button Joystick | Current Designs, Inc., Philadelphia, PA, USA |
Table 1. Specific Reagents and Equipment.
References
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