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帕金森氏病的小鼠模型：从6 - OH多巴胺病变行为测试
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Murine Model for Parkinson’s Disease: from 6-OH Dopamine Lesion to Behavioral Test
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帕金森氏病的小鼠模型：从6 - OH多巴胺病变行为测试

DOI:
10.3791/1376-v

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08:06 min

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January 15, 2010

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, , ,
1Instituto de Ciências Biomédicas,Universidade Federal do Rio de Janeiro, Brasil

Chapters

  • 00:00Title
  • 00:02Introduction
  • 00:35Materials and Instruments
  • 01:14Anesthetizing and Preparing the Animal for Surgery
  • 02:24Stereotaxic Surgery
  • 06:31Apomorphine Induced Rotation Test
  • 07:27Conclusion

Summary

Automatic Translation

Automatic Translation

帕金森病是造成损失，可实验6 - OH -多巴胺诱导的纹状体多巴胺能神经支配的。我们描述了如何执行的立体病变和监测阿朴吗啡诱导的小鼠旋转行为。这种模式是有用的，可靠的测试对帕金森病的新疗法。

Tags

Murine ModelParkinson’s Disease6-OH Dopamine LesionBehavioral TestDopaminergic CellsSubstantia NigraTremorRigidityBradykinesiaDepressionHallucinationsDementiaTreatmentMedicationsSurgical StrategiesDeep Brain StimulationCell Therapy ApproachesNeurotoxic Disruption6-hydroxydopamine (6-OHDA)MPTP (1-methyl-4-phenyl-1236-tertahydropyridine)Rodent Model

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