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Journal
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Chemistry
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Enrichment of Host Cell Proteins in Monoclonal Antibody Drug Products
/
חלבוני התא המארח (HCPs) העשרה במוצר תרופתי נוגדנים חד-שבטיים (mAb)
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Chemistry
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JoVE Journal
Chemistry
Host Cell Proteins (HCPs) Enrichment in Monoclonal Antibody (mAb) Drug Product
Please note that all translations are automatically generated.
Click here for the English version.
חלבוני התא המארח (HCPs) העשרה במוצר תרופתי נוגדנים חד-שבטיים (mAb)
Enrichment of Host Cell Proteins in Monoclonal Antibody Drug Products
DOI:
10.3791/200413-v
•
05:22 min
•
January 19, 2024
•
Sisi Zhang
,
Hui Xiao
,
Ning Li
1
Analytical Chemistry
,
Regeneron Pharmaceuticals Inc.
Tags
Host Cell Proteins
HCPs
Monoclonal Antibody
MAb
Drug Product
Enrichment
Protein Enrichment Kit
Spin Column
Wash Buffer
Elution Buffer
Trypsin
Dithiothreitol
Iodoacetamide
Trichloroacetic Acid
TFA
Desalting
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ניתוח חלבון התא המארח באמצעות חרוזי העשרה בשילוב עם עיכול מוגבל
הכנת תמיסות נוגדנים חד-שבטיים (mAb) להעשרת חלבון התא המאכסן
חלבוני התא המארח (HCPs) העשרה במוצר תרופתי נוגדנים חד-שבטיים (mAb)
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