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Automated Processor for Clinical-Scale CAR-T Cell Manufacturing

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Manufacturing Chimeric Antigen Receptor T-Cells Using an Automated Cell Processor (Video) | JoVE

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Manufacturing Chimeric Antigen Receptor T-Cells Using an Automated Cell Processor

Manufacturing Chimeric Antigen Receptor T-Cells Using an Automated Cell Processor (Video) | JoVE

Automated Processor for Clinical-Scale CAR-T Cell Manufacturing

DOI:

10.3791/200476-v

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05:11 min

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August 18, 2023

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Rene Machietto, Nicholas Giacobbe, Jessica Perazzelli, Ted J. Hofmann, Allison Barz Leahy³, Stephan A. Grupp^2,3, Yongping Wang^3,4, Stephan Kadauke^3,4

¹Cell and Gene Therapy Laboratory, Department of Pathology and Laboratory Medicine,Children’s Hospital of Philadelphia, ²Division of Oncology, Department of Pediatrics,Children’s Hospital of Philadelphia, ³Perelman School of Medicine at the University of Pennsylvania, ⁴Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine,Children’s Hospital of Philadelphia

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Keywords: Chimeric Antigen Receptor T-Cells Automated Cell Processor T-cell Transduction CD4/CD8 Selection T-cell Enrichment Activation Reagent Transduction Cell Cultivation Vector Volume

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