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Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents
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Neuroscience
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JoVE Journal Neuroscience
Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents

Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents

DOI:
10.3791/2840-v

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07:58 min

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September 15, 2011

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, , ,
1Department of Anatomy and Cell Biology, Department of Neurosurgery, Stark Neuroscience Research Institute,Indiana University School of Medicine

Chapters

  • 00:05Title
  • 01:28Making a Simple Device for Undercut Surgery
  • 03:02Preparation of the Animal for Surgery
  • 04:31Performing the Undercut Procedure
  • 06:57Results of the Undercut Procedure
  • 07:24Conclusion

Summary

Automatic Translation

Automatic Translation

Partially isolated cortex (“undercut”) is an efficient animal model of posttraumatic epileptogenesis. Here we demonstrate how to make a novel surgical device and use it to make more precise and consistent lesions to generate this model.

Tags

Undercut ModelPosttraumatic EpileptogenesisRodentsSurgical ProcedureSensorimotor CortexWhite MatterIsolated CortexCerebral CortexBrain SlicesEpileptiform DischargesElectrical SeizuresBehavior SeizuresAnimal ModelTraumatic Brain InjuryPrecise Cortical LesionsSmall Rodent BrainSurgery TechniqueSurgical DeviceCutting DepthCutting AngleConsistent ResultsStudy On Mechanisms

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