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Journal / Medicine / Heterogeneity Mapping of Protein Expression in…
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JoVE Journal Medicine
Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
 
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Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Article DOI: 10.3791/3334-v • 07:55 min • October 25th, 2011
October 25th, 2011 •
1, 2, 2, 2, 2, 1, 1
1Division of Pathology, University of Edinburgh, 2HistoRx Inc.

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Here we describe a method to quantify molecular heterogeneity in histological sections of tumor material using quantitative immunofluorescence, image analysis, and a statistical measure of heterogeneity. The method is intended for use in clinical biomarker development and analysis.

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Heterogeneity Mapping Protein Expression Tumors Quantitative Immunofluorescence Morphologic Heterogeneity Histopathologists Surgical Practice Phenotype Differences Molecular Phenotype Protein Expression Differences Cellular Function Prognosis Genetic Heterogeneity Sub-clones Metastatic Disease Biomarkers Therapeutic Responses Histopathologic Scoring Schemes Immunohistochemistry
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