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在小鼠模型中静脉自我管理的方法
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Methods for Intravenous Self Administration in a Mouse Model
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在小鼠模型中静脉自我管理的方法

DOI:
10.3791/3739-v

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12:09 min

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December 08, 2012

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, ,
1Addictions Unit,McGill University Health Centre

Chapters

  • 00:00Title
  • 00:51Preparation of Catheter Accessories
  • 02:17Catheter Preparation
  • 02:43Anesthesia
  • 03:19Surgery
  • 11:15Recovery
  • 11:27Conclusion

Summary

Automatic Translation

Automatic Translation

的静脉-的管理（IVSA）的范式被认为是研究在啮齿类动物中滥用药物的补强性的黄金标准。这手稿列出了实验步骤和手术技术必要获得可靠的IVSA的数据。特别突出，细致的导管植入术和维护。

Tags

Intravenous Self-administrationIVSA ParadigmDrug ReinforcementDrugs Of AbuseCocaineSchedule Of ReinforcementMeasurement Of Drug ConsumptionTiming And Pattern Of IV InjectionsIntravenous Route Of AdministrationConfounds Related To First Pass Metabolism Or TasteBlood And Brain Drug LevelsCatheter Placement During SurgeryDaily Catheter Flushing And MaintenanceAnimal Housing And Acclimation MethodsOperant TrainingCatheter Implantation Surgery

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