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Funktionel Neuroimaging Med Ultrasonic blod-hjerne barrieren forstyrrelser og mangan-forstærket MRI
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Chapters
- 00:05Title
- 01:52Assemble and Calibrate the Ultrasound System
- 03:03Animal Preparation
- 05:12Blood-brain Barrier Opening with Microbubbles and UltraSound (BOMUS) and Neuronal Stimulation
- 06:28Magnetic Resonance Imaging and Analysis
- 06:58Results: Functional Neuroimaging using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
- 07:54Conclusion
En teknik er beskrevet for bredt åbning af blod-hjerne-barrieren hos mus ved hjælp af mikrobobler og ultralyd. Anvendelse af denne teknik, kan mangan indgives til musehjerne. Fordi mangan er en MRI-kontrastmiddel, der ophobes i depolariserede neuroner, denne tilgang gør det muligt billeder af neuronal aktivitet.
Tags
Functional NeuroimagingUltrasonic Blood-brain Barrier DisruptionManganese-enhanced MRIMiceGenetic And Molecular Underpinnings Of NeuroscienceAIM MRINeuronal Activity MappingMn2+Calcium AnalogMRI EnhancementMn2+ ClearanceBlood-brain Barrier (BBB)UltrasoundGas-filled MicrobubblesUltrasound Contrast AgentsBBB Opening MethodPerflutren Microbubbles
