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Chapters
- 00:05Title
- 01:35Expression of Recombinant APP Intracellular Domain
- 02:55Purification of GST-AICD
- 05:23Thrombin Cleavage of GST-AICD and Purification of AICD
- 06:54AICD Aggregation for Atomic Force Microscopy
- 07:56Representative AICD Aggregation Results
- 09:32Conclusion
Tags
Amyloid Precursor ProteinAPPAlzheimer’s DiseaseAICDProteasesα-secretaseβ-secretaseγ-secretaseAβ PeptideSenile PlaquesFe65Tip60Transcription RegulationProtein-protein InteractionsHolo-APPC-terminal FragmentsAggregationMolecular Chaperone Ubiquilin-1Hydrophobic DomainsIntrinsically DisorderedStable Secondary Structure
