Medicine
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The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
Chapters
Summary
Fibroblasts from patients carrying mutations in Parkinson's disease-causing genes represent an easily accessible ex vivo model to study disease-associated phenotypes. Live cell imaging gives the opportunity to study morphological and functional parameters in living cells. Here we describe the preparation of human fibroblasts and subsequent monitoring of mitochondrial phenotypes.
Tags
Primary Human Fibroblasts Monitoring Mitochondrial Phenotypes Parkinson's Disease Ageing Risk Factor Neurodegeneration In Vitro Models Molecular Pathways Ex Vivo Models Disease-associated Mutations Skin Biopsies Culturing Human Fibroblasts Microscopic Techniques Mitochondrial Function Mitochondrial DynamicsRelated Videos
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