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1Department of Physiology and Pharmacology,Loma Linda University School of Medicine, 2College of Natural and Agricultural Sciences,University of California, Riverside , 3Department of Anesthesiology,Loma Linda University School of Medicine, 4Department of Neurosurgery,Loma Linda University School of Medicine
Chapters
- 00:00Title
- 02:15Apparatus
- 03:00Presurgical Preparations
- 04:17ICH Surgery
- 07:39Behavioral Assessment
- 08:59Representative Results
Klinisk relevante dyremodeller for intracerebral blødning (ICH) er nødvendige for at udvide kendskabet til hæmoragisk slagtilfælde og til at undersøge nye terapeutiske strategier. I denne undersøgelse beskriver vi og vurdere to ICH-modeller, der implementerer ensidige injektioner af enten autologt blod eller bakteriel collagenase i de basale ganglier (corpus striatum) af mus.
Tags
ModelingIntracerebral HemorrhageMiceAutologous BloodBacterial CollagenasePreclinical ModelsTherapeutic StrategiesPathophysiologyHemorrhage InductionInjury ProgressionBlood Injection ModelCollagenase ModelBasal Lamina DisruptionPerihematomal EdemaNeurofunctional DeficitsDouble Injection ModelCD-1 MiceNeurofunctional DeficitsBrain Edema
