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JoVE Journal Medicine
A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury
 

A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury

Article DOI: 10.3791/50149-v • 09:24 min • January 5th, 2015
January 5th, 2015 •
*1,2, *1,3, 4, 4, 4, 1,3
1Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery and Goodman and Campbell Brain and Spine, Indiana University School of Medicine, 2Medical Neuroscience Graduate Program, Indiana University School of Medicine, 3Department of Anatomy and Cell Biology, Indiana University School of Medicine, 4Norton Neuroscience Institute, Norton Healthcare
* These authors contributed equally

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Summary
Automatic Translation

Vertebral stabilization is necessary for minimizing variability, and for producing consistent experimental spinal cord injuries.  Using a customized stabilizing apparatus in conjunction with the NYU/MASCIS impactor device, we have demonstrated here the proper equipment and procedure for generating reproducible hemi-contusive cervical (C5) spinal cord injuries in adult rats.

Tags

Keywords: Vertebral Stabilization Cervical Spinal Cord Injury Animal Model Contusion Laminectomy NYU/MASCIS Impactor Stereotactic Injections Two-photon Microscopy
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