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Immunology and Infection

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JoVE Journal Immunology and Infection
The Citrobacter rodentium Mouse Model
 

The Citrobacter rodentium Mouse Model: Studying Pathogen and Host Contributions to Infectious Colitis

Article DOI: 10.3791/50222-v • 11:04 min • February 19th, 2013
February 19th, 2013 •
1, 1, 1, 1, 1, 1
1Division of Gastroenterology, BC Children's Hospital

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Summary
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Citrobacter rodentium infection provides a valuable model to study enteric bacterial infections as well as host immune responses and colitis in mice. This protocol outlines the measurement of barrier integrity, pathogen load and histological damage allowing for the thorough characterization of pathogen and host contributions to murine infectious colitis.

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Keywords: Citrobacter Rodentium Mouse Model Infectious Colitis Enteric Bacterial Infection Inflammatory Bowel Disease (IBD) Intestinal Epithelial Barrier Bacterial Colonization Host Response Pathogen Virulence Murine Pathogen EPEC EHEC
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