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Journal / Neuroscience / An Injury Paradigm to Investigate Central Nervous …
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Neuroscience

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JoVE Journal Neuroscience
An Injury Paradigm to Investigate Central Nervous System Repair in Drosophila
 

An Injury Paradigm to Investigate Central Nervous System Repair in Drosophila

Article DOI: 10.3791/50306-v • 10:49 min • March 28th, 2013
March 28th, 2013 •
1, 1
1Neurodevelopment Group, School of Biosciences, University of Birmingham

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Summary
Automatic Translation

An injury paradigm using the Drosophila larval ventral nerve cord to investigate central nervous system regeneration and repair is described. Stabbing followed by laser scanning confocal microscopy in time-lapse and fixed specimens, combined with quantitative analysis with purposefully developed software and genetics, are used to investigate the molecular mechanisms of CNS regeneration and repair.

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Keywords: Central Nervous System CNS Injury Repair Regeneration Drosophila Ventral Nerve Cord VNC Spinal Cord Laser Scanning Confocal Microscopy Immunofluorescence ImageJ Cell Proliferation Cell Death Genetics Molecular Mechanisms
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