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Bioengineering

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JoVE Journal Bioengineering
Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
 

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

Article DOI: 10.3791/50401-v • 08:08 min • June 18th, 2013
June 18th, 2013 •
1,2,3, 2, 2, 2, 1
1Department of Obstetrics, Perinatal Pharmacology, University Hospital Zurich, 2Laboratory for Materials - Biology Interactions, EMPA Swiss Federal Laboratories for Materials Testing and Research, 3Graduate School for Cellular and Biomedical Sciences, University of Bern

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Summary
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The ex vivo dual recirculating human placental perfusion model can be used to investigate the transfer of xenobiotics and nanoparticles across the human placenta. In this video protocol we describe the equipment and techniques required for a successful execution of a placenta perfusion.

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Keywords: Placental Perfusion Xenobiotics Nanomaterials Placental Barrier Ex Vivo Model Fetal Exposure Nanoparticles Polystyrene Particles Transport Rate Human Placenta
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