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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
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Bioengineering
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JoVE Journal Bioengineering
Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

DOI:
10.3791/50533-v

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12:19 min

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July 01, 2013

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, , , , , , ,
1Biomatériaux et Bioingénieriee,INSERM, 2Service Oto-Rhino-Laryngologie,Hôpitaux Universitaires de Strasbourg, 3Faculté de Chirurgie Dentaire,Université de Strasbourg

Chapters

  • 00:05Title
  • 01:24Preparation of Micropore Gradients in Macroporous Metallic Implants
  • 04:35Surface Coating of Porous Metallic Implants with Collagen/Alginate Multilayers
  • 07:50Indirect Monitoring of Implant Integration In vivo By Analysis of Blood Plasma
  • 09:33Results: Modification of Porous Metallic Implants and Analysis of Blood Plasma after Implanatation
  • 11:41Conclusion

Summary

Automatic Translation

Automatic Translation

In this video, we will demonstrate modification techniques for porous metallic implants to improve their functionality and to control cell migration. Techniques include development of pore gradients to control cell movement in 3D and production of basement membrane mimics to control cell movement in 2-D. Also, a HPLC-based method for monitoring implant integration in-vivo via analysis of blood proteins is described.

Tags

Keywords: Metallic ImplantsTitaniumPorous StructurePore GradientsPolyelectrolytesHydrophobicityHydrophilicityPLLACollagenAlginateCell MigrationTrachea RegenerationCGABlood ProteinsIn Vivo MonitoringHistology

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