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Journal / Neuroscience / Heat-Induced Antigen Retrieval: An Effective…
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JoVE Journal Neuroscience
Heat-Induced Antigen Retrieval
 

Heat-Induced Antigen Retrieval: An Effective Method to Detect and Identify Progenitor Cell Types during Adult Hippocampal Neurogenesis

Article DOI: 10.3791/50769-v • 09:38 min • August 30th, 2013
August 30th, 2013 •
*1, *1, 1, 1, 2, 1,3
1Department of Neurologic Surgery, Mayo Clinic College of Medicine, 2Department of Anatomy, Korea University College of Medicine, 3Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine
* These authors contributed equally

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Summary
Automatic Translation

During adult hippocampal neurogenesis, a distinct set of genetic markers are expressed when a quiescent neural stem cell sequentially progresses and develops into a functionally integrated neuron in the circuit. Using heat-induced antigen retrieval, progenitor cell types that are otherwise difficult to detect are identified with improved effectiveness.

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Keywords: Heat-induced Antigen Retrieval Immunohistochemistry Adult Hippocampal Neurogenesis Neural Stem Cell Progenitor Cell Types Proliferation Differentiation Maturation Functional Integration Pathophysiology
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