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Bioengineering

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JoVE Journal Bioengineering
Nonhuman Primate Lung Decellularization and Recellularization Using a Specialized Large-organ Bioreactor
 

Nonhuman Primate Lung Decellularization and Recellularization Using a Specialized Large-organ Bioreactor

Article DOI: 10.3791/50825-v • 16:45 min • December 15th, 2013
December 15th, 2013 •
1,2, 1, 1, 1, 1, 1,3, 1,3, 1,2,4
1Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, 2Division of Regenerative Medicine, Tulane National Primate Research Center, 3Department of Microbiology and Immunology, Tulane University School of Medicine, 4Department of Pharmacology, Tulane University School of Medicine

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Summary
Automatic Translation

Whole-organ decellularization produces natural biological scaffolds that may be used for regenerative medicine. The description of a nonhuman primate model of lung regeneration in which whole lungs are decellularized and then seeded with adult stem cells and endothelial cells in a bioreactor that facilitates vascular circulation and liquid media ventilation is presented.

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Keywords: Nonhuman Primate Lung Decellularization Lung Recellularization Bioartificial Tissue Regeneration Extracellular Matrix Organ Transplantation Bioreactor Mechanical Stretch Stem Cells Endothelial Cells Rhesus Macaque
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