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JoVE Journal Neuroscience
Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis
 

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Article DOI: 10.3791/50870-v • 14:58 min • February 13th, 2014
February 13th, 2014 •
1, 2, 2, 1, 1, 2
1Cell Biology, University of Bielefeld, 2Molecular Neurobiology, University of Bielefeld

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Summary
Automatic Translation

Methods for the manipulation and analysis of NF-κB-dependent adult hippocampal neurogenesis are described. A detailed protocol is presented for a dentate gyrus-dependent behavioral test (termed the spatial pattern separation-Barnes maze) for the investigation of cognitive outcome in mice. This technique should also help enable investigations in other experimental settings.

Tags

NF-κB Adult Neurogenesis Hippocampus Dentate Gyrus Spatial Pattern Separation Barnes Maze Transgenic Mouse Model Neuronal Plasticity
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