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Journal / Medicine / Primary Culture of Human Vestibular Schwannomas
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Primary Culture of Human Vestibular Schwannomas
 
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Primary Culture of Human Vestibular Schwannomas

Article DOI: 10.3791/51093-v • 10:50 min • July 20th, 2014
July 20th, 2014 •
1, 1, 1
1Department of Otolaryngology-Head and Neck, University of Iowa Hospitals and Clinics

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Vestibular Schwannomas (VSs) are non-malignant tumors of Schwann cell (SC) origin, associated with mutations in the NF2 tumor suppressor gene. We report a reproducible, efficient protocol for primary human VS cell culture that allows for molecular and cellular experimental manipulation and analysis and recapitulates the heterogeneous nature of human disease.

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Keywords: Vestibular Schwannoma Schwann Cell Tumor Neurofibromatosis Type 2 NF2 Tumor Suppressor Gene Primary Cell Culture HEI193 Cell Line HPV E6 And E7 Oncogenes Tumorigenesis
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