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Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
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Bioengineering
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JoVE Journal Bioengineering
Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

DOI:
10.3791/51467-v

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13:17 min

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May 26, 2014

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, , ,
1Department of Cardiology, Boston Children’s Hospital,Harvard Medical School, 2Department of Anesthesiology and Critical Care, Children’s Hospital of Philadelphia,University of Pennsylvania

Chapters

  • 00:05Title
  • 01:54System Set-up
  • 04:23LOM Manufacture
  • 07:33Collection, Concentration, Assessment, and Storage of LOMs
  • 10:19Results: LOMs Can Be Manufactured in High Capacity and with High Oxygen Purity by High Shear Homogenization and Serial Concentration
  • 12:39Conclusion

Summary

Automatic Translation

Automatic Translation

We describe methods for the manufacture of large volumes of lipid-based oxygen microbubbles (LOMs) designed for intravenous oxygen delivery using high-shear homogenization and serial concentration.

Tags

Lipid-based Oxygen MicrobubblesHigh Shear HomogenizationConcentrationUltrasound Contrast AgentsDrug DeliveryGas-filled MicrobubblesSurfactantsHomogenizationOxygen DeliveryHypoxemiaOrgan InjuryCardiac Arrest

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