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JoVE Journal Bioengineering
Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
 

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Article DOI: 10.3791/51467-v • 13:17 min • May 26th, 2014
May 26th, 2014 •
1, 1, 2, 1
1Department of Cardiology, Boston Children's Hospital, Harvard Medical School, 2Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, University of Pennsylvania

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Summary
Automatic Translation

We describe methods for the manufacture of large volumes of lipid-based oxygen microbubbles (LOMs) designed for intravenous oxygen delivery using high-shear homogenization and serial concentration.

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Keywords: Lipid-based Oxygen Microbubbles High Shear Homogenization Concentration Ultrasound Contrast Agents Drug Delivery Gas-filled Microbubbles Surfactants Homogenization Oxygen Delivery Hypoxemia Organ Injury Cardiac Arrest
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