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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
 

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Article DOI: 10.3791/51537-v • 09:22 min • January 2nd, 2015
January 2nd, 2015 •
*1, *1, 1
1Department of Biochemistry and Molecular Biology, Michigan State University
* These authors contributed equally

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Summary
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Unmodified and hyperphosphorylated tau proteins were used in two in vitro aggregation assays to reveal the hyperphosphorylation-dependent fast aggregation kinetics. These assays pave the way for future screens for compounds that can modulate the propensity of hyperphosphorylated tau to form fibrils that underlie the progression of Alzheimer’s disease.

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Keywords: Alzheimer's Disease Tauopathies Hyperphosphorylated Tau Neurofibrillary Tangles Tau Aggregation Assays Recombinant Tau High-throughput Screens Tau Aggregates Neurodegenerative Disorders Therapeutic Development
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