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Immunology and Infection

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JoVE Journal Immunology and Infection
Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection
 

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection

Article DOI: 10.3791/51668-v • 11:49 min • June 12th, 2014
June 12th, 2014 •
1, 2, 1, 1, 3, 1, 1
1Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies of the National Polytechnic Institute, 2Department of Molecular Biomedicine, Center for Research and Advanced Studies of the National Polytechnic Institute, 3Agency for Knowledge Commercialization, Center for Research and Advanced Studies of the National Polytechnic Institute

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Summary
Automatic Translation

Human infection by Entamoeba histolytica leads to amoebiasis, a major cause of diarrhea in tropical countries. Infection is initiated by pathogen interactions with intestinal epithelial cells, provoking the opening of cell-cell contacts and consequently diarrhea, sometimes followed by liver infection. This article provides a model to assess the early host-pathogen interactions to improve our understanding of amoebiasis pathogenesis.

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Keywords: Entamoeba Histolytica Amoebiasis Epithelial Damage Tight Junctions EhCPADH112 Host-pathogen Interaction Epithelial Barrier Dysfunction Transepithelial Electrical Resistance Epithelial Surface Receptors Epithelial Junctional Markers Parasite Localization
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