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JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells
 

Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Article DOI: 10.3791/51859-v • 08:12 min • August 11th, 2014
August 11th, 2014 •
1, 2,3, 1, 1
1Department of Pathology, Institute of Cell Engineering, Johns Hopkins University, 2Department of Internal Medicine I, University of Regensburg, 3Department of Rheumatology, Asklepios Medical Center

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Summary
Automatic Translation

Guidelines are presented for the generation of killer artificial antigen presenting cells, KaAPC, an efficient tool for in vitro depletion of human antigen-specific T cells and an alternative solution to cellular immunotherapy for the treatment of T cell-mediated autoimmune diseases in an antigen-specific fashion without compromising the remaining immune system.

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Keywords: Killer Artificial Antigen Presenting Cells KaAPC In Vitro T Cell Depletion Autoimmune Disease Treatment Cell-based Immunotherapy Antigen-specific T Cell Modulation Global Immunosuppression Tolerance-inducing Antigen Presenting Cells
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