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Ischemic Tissue Injury in the Dorsal Skinfold Chamber of the Mouse
 

Ischemic Tissue Injury in the Dorsal Skinfold Chamber of the Mouse: A Skin Flap Model to Investigate Acute Persistent Ischemia

Article DOI: 10.3791/51900-v • 10:24 min • November 17th, 2014
November 17th, 2014 •
1, 1, 2, 1, 1, 1, 1, 1, 3, 4
1Department of Plastic Surgery and Hand Surgery, Klinikum rechts der Isar, Technische Universität München, 2Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital of Basel, 3Institute for Clinical and Experimental Surgery, University of Saarland, 4Division of Plastic and Hand Surgery, University Hospital Zurich

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Summary
Automatic Translation

The window of the murine dorsal skinfold chamber presented visualizes a zone of acute persistent ischemia of a musculocutaneous flap. Intravital epi-fluorescence microscopy permits for direct and repetitive assessment of the microvasculature and quantification of hemodynamics. Morphologic and hemodynamic results can further be correlated with histological and molecular analyses.

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Keywords: Ischemic Tissue Injury Dorsal Skinfold Chamber Mouse Skin Flap Model Acute Persistent Ischemia Microvascular Architecture Hemodynamics Intravital Epi-fluorescence Microscopy Apoptosis Inflammation Microvascular Leakage Angiogenesis Preconditioning Periconditioning Postconditioning
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