A subscription to JoVE is required to view this content. Sign in or start your free trial.
Chapters
- 00:05Title
- 01:28Preparations
- 02:30Isolating the Common Carotid Artery (CCA)
- 03:29The Balloon Injury
- 05:29Intraluminal Administration of Reagents
- 06:43Closing the Wound and Pre-operative Care
- 07:43Results: Neoitima Formation with Vessel Injury
- 08:58Conclusion
This protocol uses a balloon catheter to cause an intraluminal injury on the rat carotid artery and henceforth elicit neointimal hyperplasia. This is a well-established model for studying the mechanisms of vascular remodeling in response to injury. It is also widely used to determine the validity of potential therapeutic approaches.
