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Vascular Balloon Skade og intraluminal Administration i Rat Arteria carotis
JoVE Journal
Medicine
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JoVE Journal Medicine
Vascular Balloon Injury and Intraluminal Administration in Rat Carotid Artery
DOI:

09:41 min

December 23, 2014

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Chapters

  • 00:05Title
  • 01:28Preparations
  • 02:30Isolating the Common Carotid Artery (CCA)
  • 03:29The Balloon Injury
  • 05:29Intraluminal Administration of Reagents
  • 06:43Closing the Wound and Pre-operative Care
  • 07:43Results: Neoitima Formation with Vessel Injury
  • 08:58Conclusion

Summary

Automatic Translation

Denne protokol anvender et ballonkateter til at forårsage en intraluminal skade på rotte halspulsåren og fremover fremkalde neointimahyperplasi. Dette er en veletableret model til at studere mekanismer vaskulær remodellering i respons på skade. Det er også almindeligt anvendt til at bestemme gyldigheden af ​​potentielle terapeutiske metoder.

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