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Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
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Bioengineering
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JoVE Journal Bioengineering
Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

DOI:
10.3791/53079-v

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11:13 min

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August 19, 2015

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, ,
1Department of Biomedical Engineering,National University of Singapore, 2Mechanobiology Institute, Singapore,National University of Singapore, 3Department of Surgery,National University of Singapore

Chapters

  • 00:05Title
  • 02:03Drawing of Interfacial Polyelectrolyte Complexation (IPC) Fibers
  • 03:43Fabrication of Pullulan-Dextran and IPC Fiber Composite Hydrogel Scaffolds
  • 06:36Fabrication of a Micro-patterned Polycaprolactone and IPC Fiber Composite
  • 08:25Results: Composite IPC Fiber Scaffolds Sustainably Release Bioactive Growth Factors
  • 10:03Conclusion

Summary

Automatic Translation

Automatic Translation

Scaffolds for tissue engineering need to recapitulate the complex biochemical and biophysical microenvironment of the cellular niche. Here, we show the use of interfacial polyelectrolyte complexation fibers as a platform to create composite, multi-component polymeric scaffolds with sustained biochemical release.

Tags

Interfacial Polyelectrolyte ComplexationIPC FibersComposite ScaffoldsControlled Biomolecule DeliveryPolysaccharidePolycaprolactoneTopographical CuesSustained Biochemical ReleaseCellular Niche

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