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تحريض الأم المناعي التنشيط في الفئران في مرحلة منتصف الحمل مع الفيروسية تقليد بولي (I: C)
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)
DOI:

07:13 min

March 25, 2016

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Chapters

  • 00:05Title
  • 00:57Timed-mating Pair Setup
  • 02:23Poly(I:C) Injection
  • 03:55MIA Adult Offsrping Behavioral Abnormality Evaluation
  • 05:33Results: MIA Adult Offsrping Exhibit Abnormalities Associated with Autism and Schizophrenia
  • 06:42Conclusion

Summary

Automatic Translation

Maternal immune activation (MIA) is a model for an environmental risk factor of autism and schizophrenia. The goal of this article is to provide a step-by-step procedure of how to induce MIA in the pregnant mice in order to enhance the reproducibility of this model.

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