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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Bioengineering
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JoVE Journal Bioengineering
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

DOI:
10.3791/53680-v

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09:11 min

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February 13, 2016

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, , , , ,
1Department of Biological Sciences,Kent State University, 2Liquid Crystal Institute,Kent State University, 3Chemical Physics Interdisciplinary Program,Kent State University

Chapters

  • 00:05Title
  • 01:19Preparing Surface Coated Microgels
  • 03:59Crosslinking the Microgels and Triggering Drug Release
  • 05:39Measuring Drug Release from the Microgels
  • 06:39Results: TR-BSA Release from Microgels Incorporating p(NIPAM-co-AAm) Chains and Superparamagnetic Nanoparticles
  • 08:23Conclusion

Summary

Automatic Translation

Automatic Translation

We present a facile method to fabricate a biodegradable gelatin-based drug release platform that is magneto-thermally responsive. This was achieved by incorporating superparamagnetic iron oxide nanoparticles and poly(N-isopropylacrylamide-co-acrylamide) within a spherical gelatin micro-network crosslinked by genipin, in conjunction with an alternating magnetic field application system.

Tags

Magnetic Field-responsiveHybrid Gelatin MicrogelsControlled Drug ReleaseNanoparticle Microgel HybridsMagnetothermally ResponsivePNIPAM CopolymersOn-demand Drug DeliveryEmulsionPluronic L-64 Surfactant

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