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Immunology and Infection

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JoVE Journal Immunology and Infection
An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy
 

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction

Article DOI: 10.3791/54592-v • 10:17 min • December 8th, 2016
December 8th, 2016 •
1, 1, 2, 1, *1, *1
1Department of Neurology, University Hospital Münster, 2Institute of Biochemistry, University of Münster
* These authors contributed equally

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Summary
Automatic Translation

Here, we describe an in vitro murine model of the blood-brain barrier that makes use of impedance cell spectroscopy, with a focus on the consequences on endothelial cell integrity and permeability upon interaction with activated T cells.

Tags

Keywords: Blood-brain Barrier In Vitro Model Impedance Spectroscopy T Cell-endothelial Cell Interaction Neuroimmunology Autoimmune CNS Disorders EAE Primary Endothelial Cell Culture T Cell Activation Multiple Sclerosis MBMEC
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