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En syngen musemodel af metastaserende renalcellecarcinom for Kvantitativ og Longitudinal Vurdering af Prækliniske Terapier
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1Department of Urology,University of Minnesota, 2Masonic Cancer Center,University of Minnesota, 3Microbiology, Immunology, and Cancer Biology Graduate Program,University of Minnesota, 4Department of Medical Microbiology, Immunology and Cell Biology,Southern Illinois University School of Medicine, 5Simmons Cancer Institute
Chapters
- 00:05Title
- 00:45Surgical Preparation
- 02:59Organ Harvest
- 04:43Results: Representative Tumor Burden Analyses after Tumor Cell Implantation
- 05:31Conclusion
Gennemførelse af en orthotopisk model af renalcellekarcinom i immunokompetente mus giver investigator en klinisk relevant system, defineret ved tilstedeværelsen af en primær nyretumor og lungemetastaser i det samme dyr. Dette system kan anvendes til præklinisk afprøve forskellige behandlinger in vivo.
