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Cancer Research

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JoVE Journal Cancer Research
Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
 

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Article DOI: 10.3791/54393-v • 09:29 min • September 30th, 2016
September 30th, 2016 •
1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1
1Medicine, University of Colorado Denver Anschutz Medical Campus

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Summary
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Utilizing patient-derived tumors in a subcutaneous preclinical model is an excellent way to study the efficacy of novel therapies, predictive biomarker discovery, and drug resistant pathways. This model, in the drug development process, is essential in determining the fate of many novel anti-cancer therapies prior to clinical investigation.

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Keywords: Patient-derived Tumor Xenograft PDX Model Anti-cancer Therapies Preclinical Research Tumor Heterogeneity Biomarker Discovery Drug Resistance Tissue Processing Tumor Implantation Cryopreservation Histology
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